This study investigates the effect of nursing on the incidence of breast tumors in mice. The A inbred high-cancer line was used as control and newborn young of A stock mothers were removed and fostered by females of the low-tumor C57 Black or CBA lines. It was apparent that the fostered mice and the progeny of the noncancerous fostered animals lived considerably longer than did mice from the other 2 classes. Controls had a tumor incidence of 83.6% as compared to only 7.4% of the fostered mice. Little variation was observed in the average breast tumor age of the various classes. This experiment demonstrates that the source of milk exerts a decided influence on the development of breast tumors, since mice nursed by low-tumor stock females show a low percentage of tumors, while mice nursed by high-tumor stock females have a high ratio. In general, if the mother had a breast tumor the incidence among its progeny was nearly as high as for the control stock, while young descended from noncancerous mothers usually have a low ratio. These findings, however, do not entail definite conclusions, since exceptions are rather common.
Relation of nursing to the extra-chromosomal theory of breast cancer in mice.
Abstract
This study investigates the effect of nursing on the incidence of breast tumors in mice. The A inbred high-cancer line was used as control and newborn young of A stock mothers were removed and fostered by females of the low-tumor C57 Black or CBA lines. It was apparent that the fostered mice and the progeny of the noncancerous fostered animals lived considerably longer than did mice from the other 2 classes. Controls had a tumor incidence of 83.6% as compared to only 7.4% of the fostered mice. Little variation was observed in the average breast tumor age of the various classes. This experiment demonstrates that the source of milk exerts a decided influence on the development of breast tumors, since mice nursed by low-tumor stock females show a low percentage of tumors, while mice nursed by high-tumor stock females have a high ratio. In general, if the mother had a breast tumor the incidence among its progeny was nearly as high as for the control stock, while young descended from noncancerous mothers usually have a low ratio. These findings, however, do not entail definite conclusions, since exceptions are rather common.Preview Only. This article cannot be rented because we do not currently have permission from the publisher.
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Relation of nursing to the extra-chromosomal theory of breast cancer in mice.
Bittner, J. J.
The American journal of cancer
MEDLINE Abstracts – Jan 1, 1939
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