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A study was made of the effect of immunization with formalinized MMTV on mammary tumor incidence in BALB/c mice exposed to dimethylbenzanthracene. In mice immunized with MMTV, the incidence of mammary tumours was significantly lower and the latent period longer as compared with the control group immunized with MULV. The indirect fixed immunofluorescence technique has shown that tumour cells in both groups express gp52 and p27 antigens. The possible involvement of endogenous MMTV into chemical carcinogenesis in murine mammary glands is discussed.

Possible participation of endogenous MMTV virus in chemical carcinogenesis of mouse mammary glands

Abstract

A study was made of the effect of immunization with formalinized MMTV on mammary tumor incidence in BALB/c mice exposed to dimethylbenzanthracene. In mice immunized with MMTV, the incidence of mammary tumours was significantly lower and the latent period longer as compared with the control group immunized with MULV. The indirect fixed immunofluorescence technique has shown that tumour cells in both groups express gp52 and p27 antigens. The possible involvement of endogenous MMTV into chemical carcinogenesis in murine mammary glands is discussed.

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Possible participation of endogenous MMTV virus in chemical carcinogenesis of mouse mammary glands

Komarova, E. A.; Kriukova, I. N.
Biulleten' eksperimental'noĭ biologii i meditsiny
MEDLINE Abstracts – Sep 1, 1981

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