The occurrence of 3 tar cancers of the skin, 1 uterine cancer, and 1 gastric cancer are reported in rats fed with an estrin product obtained from pregnancy urine. A tar cancer is recorded in 1 control rat. Whereas in rats injected with estrone for long periods, carcinoma of the genital tract and breast occurred accompanied by other usual estrin effects, it appears that with prolonged injection of testosterone, the females went into permanent vaginal diestrus, the pituitary weights were not above normal limits, somatic growth was not inhibited, and the predominant neoplastic lesions were fibrous tissue tumors in injected areas, some of which became sarcomatous.
Observations on rats treated with the sex hormones estrin and testosterone.
Abstract
The occurrence of 3 tar cancers of the skin, 1 uterine cancer, and 1 gastric cancer are reported in rats fed with an estrin product obtained from pregnancy urine. A tar cancer is recorded in 1 control rat. Whereas in rats injected with estrone for long periods, carcinoma of the genital tract and breast occurred accompanied by other usual estrin effects, it appears that with prolonged injection of testosterone, the females went into permanent vaginal diestrus, the pituitary weights were not above normal limits, somatic growth was not inhibited, and the predominant neoplastic lesions were fibrous tissue tumors in injected areas, some of which became sarcomatous.Preview Only. This article cannot be rented because we do not currently have permission from the publisher.
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Observations on rats treated with the sex hormones estrin and testosterone.
Mceuen, C. S.
The American journal of cancer
MEDLINE Abstracts – Aug 1, 1939
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