Intertesticular inoculation to rats of 1 ml of sarcoma suspension was accompanied by a rapid growth of the tumour at the site of inoculation and the spread of the tumour nodes to the omentum majus, porta hepatis, mesentery and the abdominal walls. After intraperitoneal inoculation the spread of the tumour nodes was similar. In these experiments animals died in 13-15 days. One month after the intratesticular inoculation of 0.2 ml of the tumour suspension-lung metastases were revealed in 74% of the animals with sarcoma-45 and in 90% of those with sarcoma-536. It was shown that tumour cells appeared in the blood stream already during the inoculation. However, laying of lung metastases occurred only after the formation of a primary tumour node at the site of transplantation. A conclusion was drawn that this system was a suitable experimental model for the study of the lung metastases development in rats.
Metastasis of sarcoma 45 and 536 following different methods of inoculation
Abstract
Intertesticular inoculation to rats of 1 ml of sarcoma suspension was accompanied by a rapid growth of the tumour at the site of inoculation and the spread of the tumour nodes to the omentum majus, porta hepatis, mesentery and the abdominal walls. After intraperitoneal inoculation the spread of the tumour nodes was similar. In these experiments animals died in 13-15 days. One month after the intratesticular inoculation of 0.2 ml of the tumour suspension-lung metastases were revealed in 74% of the animals with sarcoma-45 and in 90% of those with sarcoma-536. It was shown that tumour cells appeared in the blood stream already during the inoculation. However, laying of lung metastases occurred only after the formation of a primary tumour node at the site of transplantation. A conclusion was drawn that this system was a suitable experimental model for the study of the lung metastases development in rats.
Loading next page...
If you're having problem loading pages
Try our single-page mode to load one page at a time
Preview Only. This article cannot be rented because we do not currently have permission from the publisher.
/lp/medline/metastasis-of-sarcoma-45-and-536-following-different-methods-of-EZwgluhseK
Welcome to DeepDyve! Rent Premier Research Articles and Save Up to 90%
Preview Only
Metastasis of sarcoma 45 and 536 following different methods of inoculation
Shinkarenko, V. S.
Biulleten' eksperimental'noĭ biologii i meditsiny
MEDLINE Abstracts – Mar 1, 1976
More Info
More Like This Article
View All dataSource[]=actageo&dataSource[]=aspet&dataSource[]=aaos&dataSource[]=aacc&dataSource[]=aacr&dataSource[]=aea&dataSource[]=aip&dataSource[]=ajnr&dataSource[]=ams&dataSource[]=aps_physical&dataSource[]=appi_book&dataSource[]=appi_journal&dataSource[]=apha&dataSource[]=asip&dataSource[]=asm&dataSource[]=asn&dataSource[]=aspb&dataSource[]=annual_reviews&dataSource[]=arxiv&dataSource[]=acm&dataSource[]=berghahn&dataSource[]=cabi&dataSource[]=clinical_trials&dataSource[]=dailymed&dataSource[]=degruyter&dataSource[]=du_press&dataSource[]=esa&dataSource[]=eu_press&dataSource[]=elsevier&dataSource[]=emerald&dataSource[]=ejtr&dataSource[]=emea&dataSource[]=epo&dataSource[]=faseb&dataSource[]=gsa&dataSource[]=health_affairs&dataSource[]=hindawi&dataSource[]=imanager&dataSource[]=imedpub&dataSource[]=informa_healthcare&dataSource[]=informs&dataSource[]=iop&dataSource[]=iucr&dataSource[]=iospress&dataSource[]=jbjs&dataSource[]=leftcoast&dataSource[]=lu_press&dataSource[]=mesharpe&dataSource[]=mary_ann_liebert&dataSource[]=medline&dataSource[]=mit_press&dataSource[]=nature&dataSource[]=oxford&dataSource[]=pier_professional&dataSource[]=pnas&dataSource[]=portlandpress&dataSource[]=psyc_articles&dataSource[]=psyc_books&dataSource[]=psyc_critiques&dataSource[]=plos_journal&dataSource[]=pubmed_central&dataSource[]=rsna&dataSource[]=rockefeller&dataSource[]=rcn&dataSource[]=ria&dataSource[]=sage&dataSource[]=spie&dataSource[]=springer_journal&dataSource[]=springer&dataSource[]=taylor_francis&dataSource[]=aps&dataSource[]=the_scientist&dataSource[]=uc_press&dataSource[]=uspto_abstract&dataSource[]=wiley&dataSource[]=pct
© 2012 DeepDyve, Inc. All rights reserved.
Terms of Service | Privacy Policy
