Redistribution of concanavalin A receptors on the surface of normal and transformed cell lines was studied by indirect immunofluorescence. Normal murine fibroblasts are compared with line L transformed murine cells, whereas NRK line cells from normal rat kidney with their transformed counterparts of Ki-MSV line. It was shown that the total area occupied by the transformed cells on the substratum and the size of lamellar cytoplasm (i. e. the peripheral part attached to the substratum) are diminished as compared to those in normal cells. The surface zone from which concanavalin A-agglutinated receptors are eliminated is approximately equal to the area of lamellar cytoplasm of normal cells and is less as compared to that of transformed cells.
Quantitative patterns of concanavalin A receptor redistribution on the surface of normal and transformed cells
Abstract
Redistribution of concanavalin A receptors on the surface of normal and transformed cell lines was studied by indirect immunofluorescence. Normal murine fibroblasts are compared with line L transformed murine cells, whereas NRK line cells from normal rat kidney with their transformed counterparts of Ki-MSV line. It was shown that the total area occupied by the transformed cells on the substratum and the size of lamellar cytoplasm (i. e. the peripheral part attached to the substratum) are diminished as compared to those in normal cells. The surface zone from which concanavalin A-agglutinated receptors are eliminated is approximately equal to the area of lamellar cytoplasm of normal cells and is less as compared to that of transformed cells.
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Quantitative patterns of concanavalin A receptor redistribution on the surface of normal and transformed cells
Aleksandrova, A. Iu; Domnina, L. V.
Biulleten' eksperimental'noĭ biologii i meditsiny
MEDLINE Abstracts – Jun 1, 1980
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