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Fibroblasts from 101/H mouse fetuses manifest a higher rate of spontaneous chromosome aberrations as compared to fibroblasts from CBA fetuses. The molecular weight of single-strand DNA fragments from 101/H mice was found to be lower than that in CBA mice. No differences were disclosed in the strength of the DNA-protein bond in the cell chromatin of both mouse strains. It is assumed that the alkaline-labile-sites in DNA may be the cause of chromosome aberrations. The possibility of using 101/H mice as a model of human chromosomal instability syndromes is discussed.

Chromosome aberrations and molecular weight of single-stranded DNA fragments in embryonal fibroblasts of mouse strains 101/H and CBA

Abstract

Fibroblasts from 101/H mouse fetuses manifest a higher rate of spontaneous chromosome aberrations as compared to fibroblasts from CBA fetuses. The molecular weight of single-strand DNA fragments from 101/H mice was found to be lower than that in CBA mice. No differences were disclosed in the strength of the DNA-protein bond in the cell chromatin of both mouse strains. It is assumed that the alkaline-labile-sites in DNA may be the cause of chromosome aberrations. The possibility of using 101/H mice as a model of human chromosomal instability syndromes is discussed.
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Chromosome aberrations and molecular weight of single-stranded DNA fragments in embryonal fibroblasts of mouse strains 101/H and CBA

S'iakste, T. G.; Lil'p, I. G.; S'iakste, N. I.
Biulleten' eksperimental'noĭ biologii i meditsiny
MEDLINE Abstracts – Sep 1, 1981

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