Boosting low high-density lipoprotein (HDL) levels is a current strategy for preventing clinical events that result from cardiovascular disease. We previously showed that HDL(3) of subjects with coronary artery disease is enriched in apolipoprotein E and that the lipoprotein carries a distinct protein cargo. This observation suggests that altered protein composition might affect the antiatherogenic and antiinflammatory properties of HDL. We hypothesized that an intervention that increases HDL levels-combined statin and niacin therapy-might reverse these changes.
Combined statin and niacin therapy remodels the high-density lipoprotein proteome.
Abstract
Boosting low high-density lipoprotein (HDL) levels is a current strategy for preventing clinical events that result from cardiovascular disease. We previously showed that HDL(3) of subjects with coronary artery disease is enriched in apolipoprotein E and that the lipoprotein carries a distinct protein cargo. This observation suggests that altered protein composition might affect the antiatherogenic and antiinflammatory properties of HDL. We hypothesized that an intervention that increases HDL levels-combined statin and niacin therapy-might reverse these changes.Preview Only. This article cannot be rented because we do not currently have permission from the publisher.
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Combined statin and niacin therapy remodels the high-density lipoprotein proteome.
Green, Pattie S.; Vaisar, Tomas; Pennathur, Subramaniam; Kulstad, J. Jacob; Moore, Andrew B.; Marcovina, Santica; Brunzell, John; Knopp, Robert H.; Zhao, Xue-Qiao; Heinecke, Jay W.
Circulation
MEDLINE Abstracts – Sep 16, 2008
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