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OROS Methylphenidate-Induced Skin Eruptions

OROS Methylphenidate-Induced Skin Eruptions


Letter to the Editor OROS Methylphenidate-Induced Skin Eruptions Murat Coskun, M.D., Mustafa Deniz Tutkunkardas, M.D., and Salih Zoroglu, M.D. ethylphenidate (MPH) has rarely been reported to cause skin eruptions (SE) in subjects with attentiondeficit=hyperactivity disorder (ADHD) (Cohen et al. 1992; Confino and Goldberg 2005). Here we report the case of an 8-year-old boy with ADHD who developed maculopapular pruritic SE with OROS MPH (Concerta) but not with immediate release (IR) MPH (Ritalin) treatment. Case Report The subject is an 8-year-old boy who presented with his mother due to typical symptoms of ADHD. He was given a diagnosis of ADHD combined type with normal intellectual capacity. His prenatal, postnatal, and early developmental history was unremarkable. He had a generalized tonic–clonic seizure at 3 years of age, but has been seizure free since then. He had been on valproate 150– 250 mg=day treatment between 3 and 4 years of age. However because his control electroencephalogram (EEG) revealed abnormality, he was restarted with valproate 400 mg=day for the last 3 months. He has no known drug or food allergies so far. He has never been treated with any psychopharmacological agent except for the previous and current antiepileptic treatments. No dermatologic reactions
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