Subscribe to thousands of academic journals for just $40/month
Read and share the articles you need for your research, all in one place.

Isolation and Phylogeny of New Endogenous Retroviral Sequences Belonging to the HERV-F Family

Details

Publisher
Mary Ann Liebert, Inc.
Copyright
Copyright 2001 Mary Ann Liebert, Inc.
Subject
Sequence Notes
ISSN
0889-2229
eISSN
0889-2229
D.O.I.
10.1089/08892220150503735
Publisher site
See Article on Publisher Site

Preview Only

Expand Tray Hide Tray

Isolation and Phylogeny of New Endogenous Retroviral Sequences Belonging to the HERV-F Family

Abstract

A new human endogenous retroviral family (HERV-F) has been identified from human chromosome 7q31.1-q31.3 that was identical to the XA34 cDNA clone isolated from a human glioma cDNA library with an ERV-9 env probe. We investigated pol gene sequences of the HERV-F family from a human monochromosomal DNA panel and analyzed these with HERV-F. The pol gene sequences of the HERV-F family were detected on chromosomes 3, 6, 7, 10, 11, 14, 19, 20, X, and Y as examined by PCR. Thirty-six pol gene sequences identified from the human chromosomes have a high degree of sequence similarity (80-99%) with that of the HERV-F. Phylogenetic analysis of pol gene sequences distinctively showed four groups, indicating that the HERV-F family could be amplified at least four times after the original integration into the human genome or represent integration events separately during hominid evolution. One clone (HFY-3) on chromosome Y shared 100% sequence identity with a clone (HF19-2) on chromosome 19, and a clone (HF20-6) on chromosome 20 suggests either a recent retrotransposition or a chromosomal translocation. The history of endogenous retroviral sequences may contribute to an understanding of evolutionary change in human genomes.
Loading next page...

Preview Only. This article cannot be rented because we do not currently have permission from the publisher.

 
/lp/mary-ann-liebert/isolation-and-phylogeny-of-new-endogenous-retroviral-sequences-Ekg0BF489G