Instant Access to the Journals You Need

for just $40 per month.

Start Your Free Trial

Chemokines, Cytokines, and Inflammatory Cells in Respiratory Syncytial Virus Infection: Similarities to Allergic Responses

Chemokines, Cytokines, and Inflammatory Cells in Respiratory Syncytial Virus Infection: Similarities to Allergic Responses

Abstract

Aberrant immune responses at the time of respiratory syncytial virus (RSV) infection may explain many of the unique features of the illness caused by this virus. Immunologic hyperresponsiveness to viral antigens may explain the enhanced severity of illness in some individuals, the unfortunate experience with formalin-inactivated vaccines against RSV, and even the association of bronchiolitis with childhood asthma. In this review, we describe how RSV infection stimulates many of the same activation factors (NFκB, NF IL-6), chemokines (MIP-1α, eotaxin, RANTES), and inflammatory cells (eosinophils) that are involved in the pathogenesis of asthma. Important differences include the predominance of the Th1-like cytokine interferon gamma in RSV bronchiolitis. The potential importance of these findings in the pathogenesis of bronchiolitis and post-bronchiolitic wheezing is discussed. (Pediatric Asthma Allergy Immunol 2000;14(2):93–100.)
Loading next page...
 
/lp/mary-ann-liebert/chemokines-cytokines-and-inflammatory-cells-in-respiratory-syncytial-KN3IOSszGA

You're reading a free preview. Subscribe to read the entire article.

And millions more from thousands of peer-reviewed journals, for only $40/month.

Start Your Free Trial

What content is in DeepDyve?

  • Read and share from thousands of the leading scholarly journals from Springer, Elsevier, Nature, IEEE, Wiley-Blackwell and more.
  • All the latest content is available, no embargo periods.

Rent Scholarly Articles?

  • Read the full article in your browser.
  • Access all of your rentals from the cloud anywhere you have an internet connection.
  • Beautiful reading experience – Full charts and figures, just like the PDF.
  • Read as much as you'd like - whenever you'd like.

Happy Users

“In one word renting from DeepDyve is FANTASTIC!!! ... 99% of the time I only need access to an article for a month or so, so renting the articles is perfect for me.”

Adam S.

“Thanks for a great service! For an unaffiliated science blogger like myself this is like a dream come true.”

Seppo P.

“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”

Daniel C.

“Let me seize this opportunity and congratulate you on the service you are rendering to the scientific community.”

Joao B.