Subscribe to thousands of academic journals for just $40/month
Read and share the articles you need for your research, all in one place.

Association of PTEN Polymorphisms with Susceptibility to Hepatocellular Carcinoma in a Han Chinese Population

DNA and Cell Biology , Volume 30 (4) – Apr 1, 2011

Details

Publisher
Mary Ann Liebert, Inc.
Copyright
Copyright 2011, Mary Ann Liebert, Inc.
Subject
Original Research Articles
ISSN
1044-5498
eISSN
1557-7430
D.O.I.
10.1089/dna.2010.1126
Publisher site
See Article on Publisher Site

Preview Only

Expand Tray Hide Tray

Association of PTEN Polymorphisms with Susceptibility to Hepatocellular Carcinoma in a Han Chinese Population

Abstract

The phosphate and tension homolog ( PTEN ) is a tumor suppressor gene that controls a variety of biological processes including cell proliferation, migration, and death. The association of PTEN polymorphisms with risk for many cancers has been reported, but hepatocellular carcinoma (HCC) has not yet been studied. The present study is the first attempt to assess the association of PTEN polymorphisms with HCC susceptibility. We genotyped one insertion/deletion polymorphism (rs34421660) by polymerase chain reaction (PCR) method and three tag single-nucleotide polymorphisms (rs10490920, rs532678, and rs701848) by polymerase chain reaction–restriction fragment length polymorphism in 134 HCC patients and 215 healthy controls. We found that the four polymorphisms were not associated with HCC, at both the allele and genotype levels. However, after reconstructing PTEN haplotypes according to genotyping data and linkage disequilibrium status of four polymorphisms, we found that the T-C-C-del haplotype was associated with decreased HCC risk (odds ratio = 0.19, 95% confidence interval = 0.06–0.56) and the T-T-T-ins haplotype was associated with increased HCC risk (odds ratio = 1.63, 95% confidence interval = 1.14–2.33). Thus, our results prove that PTEN haplotypes may be associated with HCC susceptibility in a Chinese Han population.
Loading next page...

Preview Only. This article cannot be rented because we do not currently have permission from the publisher.

 
/lp/mary-ann-liebert/association-of-pten-polymorphisms-with-susceptibility-to-0dV2wIPB7U