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rat hepatocytes in the MPCC model could predict human -relevant DILI, potentially as a first step prior to use of human cultures in drug development. MATERIALS AND METHODS MATERIALS Plateable ...
was tested using 45 pharmaceutical compounds , and 91.3% of the compounds with cholestatic potential (21/23) had margins (IC50/Cmax) < 20. In contrast, 90.9% (20/22) of compounds without cholestatic potential ...
human studies addressing the mechanism of APAP-induced hepatotoxicity and the role of mitochondrial dysfunction are limited [9, 10]. Despite the extensive research that has been performed to date on APAP ...
significance of the results was assessed using one-way ANOVA. P-values less than 0.05 were considered statistically significant. Results Primary human hepatocytes We performed induction studies with five ...
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