Restorative Neurology and Neuroscience 28 (2010) 637â709 DOI 10.3233/RNN-2010-0576 IOS Press Topic: Astrogliosis PP II-1 Genetic fate mapping of polydendrocytes in the mouse cortex after focal cerebral ischemia P. Honsaa,b , H. Pivonkovaa,b and M. Anderovaa,b a Institute of Experimental Medicine AS CR, v.v.i., Department of Cellular Neurophysiology, Prague, Czech Republic b 2nd Faculty of Medicine Charles University in Prague, Prague, Czech Republic Polydendrocytes (also known as NG2 glial cells) are the last type of glial cells to be discovered in the adult mammalian central nervous system (CNS). They can be characterized by the expression of NG2 chondroitin sulfate proteoglycan and by their highly branched morphology, and they are uniformly distributed throughout the grey and white matter. It is well known that these cells differentiate into oligodendrocytes in vivo and have often been equated with oligodendrocyte precursor cells. Some recent studies have described their differentiation into ventral protoplasmic astrocytes; however, their full differentiation potential in the uninjured or injured CNS still remains elusive. To follow the differentiation fate of polydendrocytes after CNS injury we used transgenic mice (B6; FVBTg(Cspg4-cre)1Akik/J) in which Cre recombinase is expressed under the chondroitin sulfate proteoglycan (Cspg4) promotor. After breeding with reporter mice (Tg(CAG-Bgeo/GFP)21Lbe/J),
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