Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Plastic events in the vestibular nuclei during vestibular compensation: The brain orchestration of a "deafferentation" code

Plastic events in the vestibular nuclei during vestibular compensation: The brain orchestration... Restorative Neurology and Neuroscience 28 (2010) 15–31 DOI 10.3233/RNN-2010-0509 IOS Press Michel Lacour∗ and Brahim Tighilet ˆ Aix-Marseille Universit´ , UMR 6149 Universit´ de Provence/CNRS Pole 3C, Case B, Marseille Cedex 03, France e e 1. Introduction Contrary to the view of a rigid, hardwired adult central nervous system (CNS) that was commonly accepted up to a few decades ago (Ramon y Cajal, 1928), the adult CNS is now seen as continuously reorganizing throughout the life course. Adaptive plasticity, consisting of both structural reorganization and modifications of the functional properties of neuronal networks, has been shown to result from changing environments, aging, trauma/stroke, and other stressors. One characteristic example of neuroplastic CNS recovery after injury is illustrated by the vestibular lesion model. The vestibular nuclei (VN) in the brain stem can be experimentally deafferented by lesioning the peripheral sensory receptors on one side, a procedure known as unilateral labyrinthectomy (UL), or by sectioning the vestibular nerves through a unilateral vestibular neurectomy (UVN), and these two models of unilateral functional and structural deafferentation produce distinct vestibular pathologies (Lacour et al., 2009). Similar vestibular syndromes are observed in animal models of unilateral vestibular loss (Dieringer, 1995, for review) and in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Restorative Neurology and Neuroscience IOS Press

Plastic events in the vestibular nuclei during vestibular compensation: The brain orchestration of a "deafferentation" code

Loading next page...
 
/lp/ios-press/plastic-events-in-the-vestibular-nuclei-during-vestibular-compensation-Zg1ZwH0er2

References (142)

Publisher
IOS Press
Copyright
Copyright © 2010 by IOS Press, Inc
ISSN
0922-6028
eISSN
1878-3627
DOI
10.3233/RNN-2010-0509
pmid
20086280
Publisher site
See Article on Publisher Site

Abstract

Restorative Neurology and Neuroscience 28 (2010) 15–31 DOI 10.3233/RNN-2010-0509 IOS Press Michel Lacour∗ and Brahim Tighilet ˆ Aix-Marseille Universit´ , UMR 6149 Universit´ de Provence/CNRS Pole 3C, Case B, Marseille Cedex 03, France e e 1. Introduction Contrary to the view of a rigid, hardwired adult central nervous system (CNS) that was commonly accepted up to a few decades ago (Ramon y Cajal, 1928), the adult CNS is now seen as continuously reorganizing throughout the life course. Adaptive plasticity, consisting of both structural reorganization and modifications of the functional properties of neuronal networks, has been shown to result from changing environments, aging, trauma/stroke, and other stressors. One characteristic example of neuroplastic CNS recovery after injury is illustrated by the vestibular lesion model. The vestibular nuclei (VN) in the brain stem can be experimentally deafferented by lesioning the peripheral sensory receptors on one side, a procedure known as unilateral labyrinthectomy (UL), or by sectioning the vestibular nerves through a unilateral vestibular neurectomy (UVN), and these two models of unilateral functional and structural deafferentation produce distinct vestibular pathologies (Lacour et al., 2009). Similar vestibular syndromes are observed in animal models of unilateral vestibular loss (Dieringer, 1995, for review) and in

Journal

Restorative Neurology and NeuroscienceIOS Press

Published: Jan 1, 2010

There are no references for this article.