# Negative correlation between plasma fibrinogen and insulin sensitivity measured with the minimal model technique

8 pages

### Abstract

We aimed at investigating relationship between plasma fibrinogen and insulin sensitivity, which are two major determinants of metabolic Syndrome X (insulin resistance syndrome). We designed a prospective study of 27 non-diabetic, non-hypertensive subjects, presenting a wide range of body mass index BMI (10 men, 17 women; mean age {}\pm{} SEM: 35.9 {}\pm{} 2.2 years; BMI ranging from 21.145.2 kg/m ^{2} ). Insulin sensitivity was assessed with the minimal model procedure, over a 180 min intravenous glucose tolerance test with iterative sampling. Fibrinogen levels were determined by the method of Clauss. The insulin sensitivity index SI (i.e., the slope of the doseresponse relationship between insulin increased above baseline and glucose disposal) ranged from 0.0009 to 16 \times 10^{-4} min ^{-1} /( \mu U/ml), with a mean value of 4.76\pm0.73 \times 10^{-4} . Mean values of plasma fibrinogen were 3.33 {}\pm{} 0.13 g/l, ranging from 2.21 to 5.07 g/l. There were highly significant negative correlations between SI and the level of plasma fibrinogen ( r= - 0.61 , p= 0.0007 ) and between the basal effect of insulin BIE and plasma fibrinogen ( r = - 0.521 , p= 0.005 ). Basal insulin was positively correlated to fibrinogen ( r = 0.386 , p = 0.046 ). When we analysed the data using partial correlation analysis, the negative relation between SI and fibrinogen was maintained independently from BMI ( r = - 0.45 , p < 0.05 ). These data establish a strong negative association between insulin sensitivity and fibrinogen, involved in the increased cardiovascular risk of metabolic Syndrome X.

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### Article Details

Title
Negative correlation between plasma fibrinogen and insulin sensitivity measured with the minimal model technique
Author(s)
E. Raynaud; J.F. Brun; A. Perez-Martin; A. Orsetti; M. Solère
Journal
Clinical Hemorheology and Microcirculation , Volume 18 (4) IOS Press – Jan 1, 1998
Publisher
IOS Press