Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
Journal of Alzheimerâs Disease 11 (2007) 431â432 IOS Press Commentary Akihiko Takashima Laboratory for Alzheimerâs Disease, RIKEN, Brain Science Institute. 2-1 Hirosawa, Wako, Saitama 351-0198, Japan While epidemiological studies have suggested that aluminum is a risk factor for Alzheimer disease (AD), the underlying mechanism through which aluminum leads to AD remains unknown. Despite the lack of evidence linking aluminum to AD that have motivated many to avoid using materials such as cooking utensils made with the metal, researchers have yet to investigate the precise effects of aluminum on neurons . One reason for the lack of research on aluminum in AD is that, until recently, no sufï¬cient model for AD was available for more investigations. AD is pathologically deï¬ned by neuronal loss, amyloid-β (Aβ) deposition, and neuroï¬brillary tangle (NFT) formation, and recently developed mouse models of AD show Aβ deposits or NFTs formation, and a few show both [4,6,9,14,15]. These models show only some of the pathogenic changes of AD, and, as pointed out in the accompanying commentary and review paper, are therefore incomplete representations of this disease. It is for these reasons that some researchers use the rabbits injected with aluminum-malate as a model for AD, because
Journal of Alzheimer's Disease – IOS Press
Published: Jan 1, 2007
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.