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Does Aluminum Contribute to Alzheimer Disease Directly, Indirectly, or At All?

Does Aluminum Contribute to Alzheimer Disease Directly, Indirectly, or At All? Journal of Alzheimer’s Disease 11 (2007) 431–432 IOS Press Commentary Akihiko Takashima Laboratory for Alzheimer’s Disease, RIKEN, Brain Science Institute. 2-1 Hirosawa, Wako, Saitama 351-0198, Japan While epidemiological studies have suggested that aluminum is a risk factor for Alzheimer disease (AD), the underlying mechanism through which aluminum leads to AD remains unknown. Despite the lack of evidence linking aluminum to AD that have motivated many to avoid using materials such as cooking utensils made with the metal, researchers have yet to investigate the precise effects of aluminum on neurons . One reason for the lack of research on aluminum in AD is that, until recently, no sufficient model for AD was available for more investigations. AD is pathologically defined by neuronal loss, amyloid-β (Aβ) deposition, and neurofibrillary tangle (NFT) formation, and recently developed mouse models of AD show Aβ deposits or NFTs formation, and a few show both [4,6,9,14,15]. These models show only some of the pathogenic changes of AD, and, as pointed out in the accompanying commentary and review paper, are therefore incomplete representations of this disease. It is for these reasons that some researchers use the rabbits injected with aluminum-malate as a model for AD, because http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Alzheimer's Disease IOS Press

Does Aluminum Contribute to Alzheimer Disease Directly, Indirectly, or At All?

Journal of Alzheimer's Disease , Volume 11 (4) – Jan 1, 2007

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Publisher
IOS Press
Copyright
Copyright © 2007 by IOS Press, Inc
ISSN
1387-2877
eISSN
1875-8908
Publisher site
See Article on Publisher Site

Abstract

Journal of Alzheimer’s Disease 11 (2007) 431–432 IOS Press Commentary Akihiko Takashima Laboratory for Alzheimer’s Disease, RIKEN, Brain Science Institute. 2-1 Hirosawa, Wako, Saitama 351-0198, Japan While epidemiological studies have suggested that aluminum is a risk factor for Alzheimer disease (AD), the underlying mechanism through which aluminum leads to AD remains unknown. Despite the lack of evidence linking aluminum to AD that have motivated many to avoid using materials such as cooking utensils made with the metal, researchers have yet to investigate the precise effects of aluminum on neurons . One reason for the lack of research on aluminum in AD is that, until recently, no sufficient model for AD was available for more investigations. AD is pathologically defined by neuronal loss, amyloid-β (Aβ) deposition, and neurofibrillary tangle (NFT) formation, and recently developed mouse models of AD show Aβ deposits or NFTs formation, and a few show both [4,6,9,14,15]. These models show only some of the pathogenic changes of AD, and, as pointed out in the accompanying commentary and review paper, are therefore incomplete representations of this disease. It is for these reasons that some researchers use the rabbits injected with aluminum-malate as a model for AD, because

Journal

Journal of Alzheimer's DiseaseIOS Press

Published: Jan 1, 2007

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