Clinical Hemorheology and Microcirculation 20 (1999) 241â326 IOS Press 1. Plenary lectures L1. Hemorheology and endothelial cells J.F. Stoltz, S. Muller, X. Wang, V. Latger and S. Sun Dept. Hématologie, Faculté de Médecine, 54500, Vandoeuvre Les Nancy, France The vascular endothelium, a biologically active monolayer of cells (synthesis and secretion of vasoconstrictors, vasodilatators, growth factors, adhesion molecules), provided an interface between the blood ï¬ow and tissues. Endothelial cells are continually subjected to the hemodynamic forces, in particular to local shear-stresses. Of special interest are the effects of disturbed ï¬ow on the endothelial cell functions at vascular peculiarities (bifurcation, stenosis, aneurisms, . . .) locations know for favour thrombosis, and artherosclerosis. Now, in vitro studies with ï¬ow systems have demonstrated that wall shear stresses can modulate various aspects of endothelial structure and function. These effects appear to result from regulation of a mechano-transduction phenomenon through the shear-stress parameters. Changes in morphology and cytoskeleton organization were responses to mechanical perturbation on ï¬ow and leads alteration on metabolic functions through membrane âmechano-receptorsâ. It has been shown that a selective regulation of adhesion molecules (ICAM, VCAM, Selectines,. . .) and proto-oncogenes (c-fos, c-myc,. . .) expression appears directly related to shear-stress, as
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, Volume 20 (4)
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