(+-)-2-(4-Chlorophenoxy)-2-phenylpropionic acid
Abstract
<h2>Acta Crystallographica Section B</h2><h3>Structural Crystallography and Crystal Chemistry</h3><h3>0567-7408</h3> <h2>short structural papers</h2> Volume 37 Part 6 Pages 1314-1317 June 1981 <h2>(+-)-2-(4-Chlorophenoxy)-2-phenylpropionic acid</h2> C. H. L. Kennard, G. Smith and A. H. White Acta Cryst. (1981). B37, 1314-1317 (_+)-2-(4-Chlorophenoxy)-2-phenylpropionic Acid BY COLIN H. L. KENNARD Department of Chemistry, University of Queensland, Brisbane 4067, Australia GRAHAM SMITH Department of Chemistry, Queensland Institute of Technology, Brisbane 4000, Australia AND ALLAN H. WHITE Department of Physical and Inorganic Chemistry, University of Western Australia, Nedlands 6009, Western Australia (Received 14 October 1980; accepted 13 January 1981) Abstract. C15H~3CIO3, m.p. 379-381 K, Mr = 276.7, monoclinic, P2~/c, a = 15.328 (8), b -- 6.079 (5), c -- 16.398 (7) A, fl = 113.79 (3)o, Z = 4, Dx = 1.314 Mg m-3, /l(Mo Ka) = 0.278 mm-l, R = 0.086, 918 observed reflexions. The molecules, which form hydro- gen-bonded cyclic dimers [O...O, 2.638 (9)Al, adopt a conformation with the phenoxy and benzene rings 0567-7408/81/061314-04501.00 nearly coplanar. The carboxylic acid group has the syn-anti conformational motif relative to the phenoxy residue, common to all known phenoxyalkanoic acids having tertiary substitution about the a-carbon. Introduction. The title compound is an experimental anti-hypolipidaemic compound from the Merck Corn-