Instant Access to the Journals You Need

for just $40 per month.

Start Your Free Trial

Zopiclone-associated methemoglobinemia and renal impairment

Zopiclone-associated methemoglobinemia and renal impairment


Introduction To the Editor: Zolpidem, zaleplon, and eszopiclone are commonly prescribed sedative-hypnotic drugs in the United States ( 1 ). Zopiclone has safety profile similar to that of benzodiazepines ( 2 ). Following acute zopiclone overdose, the main feature is central nervous system depression, but cases of two patients who developed methemoglobinemia were reported recently ( 3 ). We report a case of zopiclone overdose associated with methemoglobinemia and renal impairment. Case report A 53-year-old woman presented to the emergency department 60 h after she took 2,250 mg of zopiclone in a suicide attempt. She slept at home for 1 day after the overdose. When she awoke, she had a headache and felt dizzy. She had no fever, rash, or joint pain. She had been previously healthy (except for a flare-up of psoriasis), was taking no medications, and had normal renal function tests 2 months before. Her blood pressure was 117/53 mmHg and pulse rate was 77 beats/minute. She was alert and cyanotic. Bedside pulse oximeter showed an oxygen saturation of 86% (not corrected with supplementary oxygen). Physical examination was otherwise unremarkable. She had satisfactory urine output of more than 150 mL/h. Her blood methemoglobin level was 19.4%.
Loading next page...

You're reading a free preview. Subscribe to read the entire article.

And millions more from thousands of peer-reviewed journals, for only $40/month.

Start Your Free Trial

What content is in DeepDyve?

  • Read and share from thousands of the leading scholarly journals from Springer, Elsevier, Nature, IEEE, Wiley-Blackwell and more.
  • All the latest content is available, no embargo periods.

Rent Scholarly Articles?

  • Read the full article in your browser.
  • Access all of your rentals from the cloud anywhere you have an internet connection.
  • Beautiful reading experience – Full charts and figures, just like the PDF.
  • Read as much as you'd like - whenever you'd like.

Happy Users

“In one word renting from DeepDyve is FANTASTIC!!! ... 99% of the time I only need access to an article for a month or so, so renting the articles is perfect for me.”

Adam S.

“Thanks for a great service! For an unaffiliated science blogger like myself this is like a dream come true.”

Seppo P.

“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”

Daniel C.

“Let me seize this opportunity and congratulate you on the service you are rendering to the scientific community.”

Joao B.