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/β/γ Midkine Interferon inducible protein-10 Nitric oxide IL-4, IL-12, and IL-18 PIGF Kringle 5 (plasminogen fragment) Platelet-derived endothelial cell growth factor (PD- ECGF ) Metalloproteinase ...
growth factor ( VEGF ) and basic fibroblast growth factor (bFGF) induce microvascular endothelial cell (MEC) migration Condition Early passage MEC (P4) Late passage MEC (P12) The migration of MEC ...
- induced endothelial cell proliferation and migration [3,8,12,13]. Our results demonstrate that NO is also an upstream promoter of VEGF expression. We found that the low concentration of NO obtained after ...
studies of novel therapeutic interventions directed at VEGF and its receptors. The Biology of VEGF and Its Receptors VEGF regulates several endothelial cell functions, including mitogenesis, permeability ...
permeability [3]. This enhanced permeability leads to subsequent fibrin deposition in the extracellular matrix that can then serve as a scaffold for migrating endothelial cells . The three VEGFRs ...
system in human glioblastoma. Lab Invest. 80 , 1681 -1689. El-Obeid, A., Bongcam-Rudloff, E., Sorby, M., Ostman, A., Nister, M., and Westermark, B. ( 1997 ) Cell scattering and migration induced ...
of existing vessels degrade the underlying basement membrane, migrate and proliferate in the perivascular stroma to form capillary sprouts. These sprouting endothelial cells stop proliferating, align, form ...
, perivascular mural cells are stimulated to detach from the outer vessel wall by angiopoietin (Ang)-2 (Augustin et al., 2009). In consequence, the endothelial cells migrate into the surrounding tissue, resulting ...
]. Although, it has been initially reported that Ang1 failed to induce capillary-like tube formation in collagen matrices [19,27], Hayes et al. [28] reported that treatment of bovine aortic endothelial cells ...
. With VEGF , Ang-2 promotes neovascularization. Angiostatin + − Plasminogen cleavage fragment; angiogenic inhibitor; inhibitor of endothelial cell proliferation and migration Amphiregulin + − EGF-like ligand ...
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