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was blocked with carbenoxolone, cortisol mimicked the nongenomic aldosterone effect on human vascular tissue . Also, eplerenone blocked the biphasic effect of aldosterone on the Na pump activity in isolated rat ...
decrease in forearm blood flow when picomolar levels of aldosterone are closely infused in vivo (4) equally clearly opens another possible role for aldosterone , that of a rapid, direct vasoconstrictor effect ...
tissues lacking 11β-hydroxysteroid dehydrogenase type 2, the role of aldosterone -mediated effects is not clearly understood and indeed the principal ligand for the MR may, in fact, be cortisol (8). Only ...
in identification and description of the putative aldosterone receptor responsible for the elastogenic action. Effects of aldosterone in the vascular tissue Cachofeiro et al. [11] summarized the deleterious effects ...
in the heart, kidneys and blood vessels. These deleterious effects include cardiac and renal fibrosis, inflammation and vascular remodeling. Aldosterone is generally considered as the main ligand of MR. However ...
of cardiovascular functions (43). The main known effects of aldosterone in classical target tissues are mediated via changes in transcription. On the other hand, genes that mediate direct cardiovascular effects ...
/day), or placebo was added to chow (n=7 per group). After the animals were killed, vascular function of isolated renal artery segments was assessed by isometric tension recording. Results. Relaxation ...
. Cortisol is inactivated by 11-beta hydroxysteroid dehydrogenase-2 (11βHSD2) in aldosterone -responsive tissues such as the kidney.10 11βHSD2 has also been found in human EC and SMC,11,12 thus vascular MR can ...
dysfunction, vasculopathy, vascular remodeling, and renal injury (5). Mineralocorticoid receptor antagonists alleviate these deleterious effects . Thus, understanding the factors that regulate aldosterone ...
Abstract The renin-angiotensin- aldosterone system was studied in patients with renovascular hypertension. When a liberal sodium diet was used, aldosterone excretion rate was increased in four of 14 ...
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