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The Study of Anticardiolipin Antibodies and Interleukin-6 in Cerebrospinal Fluid and Blood of Chinese Patients with Systemic Lupus Erythematosus and Central Nervous System Involvement

Autoimmunity , Volume 18 (3) – Jan 1, 1994

Details

Publisher
Informa UK Ltd
Copyright
© 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
Subject
Original Article
ISSN
0891-6934
eISSN
1607-842X
D.O.I.
10.3109/08916939409007993
Publisher site
See Article on Publisher Site

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The Study of Anticardiolipin Antibodies and Interleukin-6 in Cerebrospinal Fluid and Blood of Chinese Patients with Systemic Lupus Erythematosus and Central Nervous System Involvement

Abstract

Anticardiolipin (ACL) antibodies and interleukin-6 (IL-6) in cerebrospinal fluid (CSF) may be involved in the mechanism of lupus patients with central nervous system (CNS) involvement. ACL antibodies of 3 isotypes and IL-6 were measured in paired CSF and serum samples from 14 lupus patients with CNS involvement, 5 lupus patients without CNS involvement and 7 patients with non-inflammatory neurological diseases. ACL antibodies, IgG and IgM isotypes, and IL-6 were significantly increased in CSF from lupus patients with CNS involvement as compared with other 2 groups of patients. Both ACL antibodies and IL-6 decreased after neurological activity subsided. These results suggest increased ACL antibodies and IL-6 in CSF are involved in immune responses within CNS in lupus patients. Quantitation of CSF ACL antibodies may be helpful in evaluating neurological activity of lupus patients with CNS involvement.
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