Instant Access to the Journals you Need

Read Online + Print Articles, for just $40 a month.

Start Your Free Trial

The Enzymatic Synthesis of 3-Aceto-Penams Using Isopenicillin N Synthase

The Enzymatic Synthesis of 3-Aceto-Penams Using Isopenicillin N Synthase


The synthesis of L-α-aminoadipoyl-L-cysteinyl-D-(2-amino-3-methylpropa-3,4-dienoic acid) and its subsequent incubation with isopenicillin N synthase (IPNS) was carried out. A single bicyclic product was detected by 'Hn.m.r. of the crude incubation mixture. Purification by reverse phase h.p.l.c. yielded a product assigned as a new penicillin, containing a 3-α-aceto group. The mechanism for the enzymatic conversion may be rationalised in terms of an enzyme bound iron oxene moiety (or its equivalent).
Loading next page...

You're reading a free preview. Subscribe to read or print the entire article.

And millions more from thousands of peer-reviewed journals, for just $40/month.

Start Your Free Trial

What content is in DeepDyve?

  • Read and share from thousands of the leading scholarly journals from Springer, Elsevier, Nature, IEEE, Wiley-Blackwell and more.
  • All the latest content is available, no embargo periods.

Rent Scholarly Articles?

  • Read the full article in your browser.
  • Each month you can print 20 pages for free.
  • Access all of your rentals from the cloud anywhere you have an internet connection.
  • Beautiful reading experience – Full charts and figures, just like the PDF.
  • Read as much as you'd like - whenever you'd like.

Happy Users

“In one word renting from DeepDyve is FANTASTIC!!! ... 99% of the time I only need access to an article for a month or so, so renting the articles is perfect for me.”

Adam S.

“Thanks for a great service! For an unaffiliated science blogger like myself this is like a dream come true.”

Seppo P.

“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”

Daniel C.

“Let me seize this opportunity and congratulate you on the service you are rendering to the scientific community.”

Joao B.