Read Unlimited Journals

for just $9.99 per month.

Start Your Free Trial

The Enzymatic Synthesis of 3-Aceto-Penams Using Isopenicillin N Synthase

The Enzymatic Synthesis of 3-Aceto-Penams Using Isopenicillin N Synthase

Abstract

The synthesis of L-α-aminoadipoyl-L-cysteinyl-D-(2-amino-3-methylpropa-3,4-dienoic acid) and its subsequent incubation with isopenicillin N synthase (IPNS) was carried out. A single bicyclic product was detected by 'Hn.m.r. of the crude incubation mixture. Purification by reverse phase h.p.l.c. yielded a product assigned as a new penicillin, containing a 3-α-aceto group. The mechanism for the enzymatic conversion may be rationalised in terms of an enzyme bound iron oxene moiety (or its equivalent).
Loading next page...
 
/lp/informa-healthcare/the-enzymatic-synthesis-of-3-aceto-penams-using-isopenicillin-n-oN4PIYMav2

You're reading a free preview. Subscribe to read the entire article.

And millions more from thousands of peer-reviewed journals, for only $9.99/month.

Start Your Free Trial