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was designed to target EGF receptor ( EGF R) overexpressed on the surface of cancer cells through an EGF R–binding oligopeptide (GE7), was used for in vivo gene therapy in a murine subcutaneous hepatoma model ...
EGFR. However, cells expressing constitutive levels of the target receptor were barely affected. Peptabody‐ EGF treated cancer cells exhibited typical characteristics of apoptosis, which was found ...
-acid ligand for identifying EGF receptor was constructed for tumor- targeted gene therapy . Intravenous administration of GE7 system revealed that it has the ability to target β-galactosidase (β-gal ...
production of GE11 and GE11 conjugates, confer polyIC/PPGE11 a significant advantage over similar EGF ‐based polyplexes as a potential therapy of EGFR overexpressing tumors. © 2012 IUBMB Life, 64(4): 324–330 ...
, inhibition of the EGF -R pathway provides an ideal target for molecular therapy . We examined in vitro and in vivo effects of PKI166, an orally administered EGF -R inhibitor, on 2 human squamous cell carcinoma ...
than receptor activation. Mol Cancer Res . 2006 ; 4 : 27 –37. Crossref Search ADS PubMed 8 Ennis BW, Lippman ME, Dickson RB. The EGF receptor system as a target for antitumor therapy . Cancer Invest ...
activity in combination with chemotherapy (11) and radiation therapy (12). The first antibody with comparable growth inhibitory properties against the HER2 receptor targeted the rat neu receptor , which ...
for cell surface receptor targeting therapies Receptor type . SC-delivered antitumor targeting agent . Expression in tumor cells and cells of the tumor microenvironment . References . TNFRs Death receptors 4 ...
be a potential target for antitumor molecular therapy with gefitinib. We found no correlation between responsiveness to gefitinib and HER2 overexpression within the panel of MB cell lines as a whole, perhaps ...
of signal transduction molecular pathways targeted by new anticancer therapies . Abbreviations: CDK, cyclin-dependent kinase; EGFR, epidermal growth factor receptor ; ERK, extracellular signal–regulated kinase ...
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