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of the adenomas. Taken together these data support efforts to initiate clinical studies to investigate the effect of Cox‐2 inhibitors as chemotherapeutic agents and as adjuvant treatment modalities against gastric ...
molecule of Th2 cells (CRTH2) has been shown to mediate the chemotactic effect of PGD2. PGH2 is the common precursor of all PGs and is produced by several cells that express cyclooxygenases. In this study ...
of cardiovascular events. Objectives To study the effects of COX2 inhibitor rofecoxib on platelet function using in vitro tests. Results were compared with those obtained in a parallel experiment with acetyl ...
inhibitor on low molecular weight hyaluronic acid fragment-induced PGE2 release To validate the hypothesis that exogenously applied UTI inhibits prostanoid formation, we studied the effect of UTI in amnion ...
by osteoblastic cells. This study was undertaken to investigate whether celecoxib (a selective COX-2 inhibitor ) has a direct effect on human osteoclast precursors to influence osteoclastogenesis in vitro. Human ...
that COX‐1 inhibitory effects can be detected for all selective COX‐2 inhibitors tested by use of a sensitive assay at low substrate concentration. The novel inhibitor DFU shows the lowest inhibitory potency ...
Background Prostanoids are important regulators of platelet aggregation and thrombotic arterial diseases. Their involvement in the development of portal vein thrombosis, frequent in decompensated ...
prostanoids , prostaglandin I2, thromboxane A2 and prostaglandin F2α. The inhibitory effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on prostanoid production were tested on yeast cells expressing PGHS-1 ...
is also involved in platelet aggregation, facilitating activation through the EP3 receptor.22 Aside from a modulatory effect on platelet activity, prostanoids are also implicated in atherosclerosis ...
, thrombospondin, plasminogen activator inhibitor -1, and von Willebrand factor. Dense granules are rich in serotonin, ADP and calcium. Upon platelet activation, platelets lose their discoid shape, become spherical ...
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