DeepDyve – unlimited articles from the top peer-reviewed journals – Just $9.99/month.

Stay on top of your field and complete your research – Get started with a Free Trial. Signup only takes 60 seconds!

Short-Chain Fatty Acids in the Small-Bowel Bacterial Overgrowth Syndrome


Informa UK Ltd
© 1985 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
Original Article
Publisher site
See Article on Publisher Site

Preview Only

Expand Tray Hide Tray

Short-Chain Fatty Acids in the Small-Bowel Bacterial Overgrowth Syndrome


The short-chain fatty acids (SCFAs) have been measured by gas chromatography in fasting jejunal secretions, saliva, and feces from 8 patients with the small-bowel bacterial overgrowth syndrome (BO) and 9 control patients; in jejunal secretions and saliva from 6 healthy subjects; and in feces from 20 healthy subjects. The concentrations of SCFAs (median (range), mUmol/l) in jejunal secretions of BO patients were as follows: total, 990 (210-12,370); acetic acid, 650 (170-6770); propionic acid, 110 (16-3070); isobutyric acid, 26 (1-310); n -butyric acid, 90 (12-1340); isovaleric acid, 35 (2-680); n -valeric acid, 7 (3-200). In BO patients the total concentration of SCFAs in jejunal secretions was approximately four times higher than in control patients (p < 0.01) and in healthy subjects (p < 0.025). The relative distribution of the acids resembled the distribution found in feces more than that of saliva or the normal jejunal secretions. These findings indicate that patients with BO have a colonlike flora in the small intestine and that the main part of the SCFAs in the jejunal secretions of these patients is produced by the altered microbial flora in the jejunum. Combined with other tests, analyses of intestinal SCFAs may prove to be valuable in the diagnosis of small-bowel bacterial overgrowth.
Loading next page...

Preview Only. This article cannot be rented because we do not currently have permission from the publisher.