Severe Syndrome of Inappropriate Antidiuretic Hormone Secretion with Docetaxel Treatment in Metastatic Breast Cancer

Severe Syndrome of Inappropriate Antidiuretic Hormone Secretion with Docetaxel Treatment in Metastatic Breast Cancer

Abstract

CASE REPORT Severe Syndrome of Inappropriate Antidiuretic Hormone Secretion with Docetaxel Treatment in Metastatic Breast Cancer Christiane Langer-Nitsche, Hans-Joachim Luck and Monika Heilmann È From the Departments of Obstetrics and Gynaecology (C. Langer-Nitsche, H.-J. Luck) and Internal Medicine È (M. Heilmann), University of Hanover Medical School, Oststadtkrankenhaus , Hanover, Germany Correspondence to: Christiane Langer-Nitsche, Frauenklinik der MHH im Oststadtkrankenhaus , Podbielskistrasse 380 DE-30659 Hanover, Germany. Tel: » 49 (0)511 90 60. Fax: » 49 (0)511 90 63 391 Acta Oncologica Vol. 39, No. 8, p. 1001, 2000 Received 13 March 2000 Accept ed 31 May 2000 We report the case of a 76-year-old female with metastatic breast cancer who developed severe syndrome of inappropriate antidiuretic hormone secretion (SIADH) during treatment with docetaxel. Our patient was rst diagnosed with receptor-negative lobular breast cancer T2N1M0 in August 1996. Breast-conserving surgery was performed, the patient receiving standard irradiation and adjuvant chemotherapy with anthracyclines and cyclophosphamide. In October 1998, when bone metastases developed, the patient was started on tamoxifen and iv-bisphosphonates. By January 1999 the disease had progressed and treatment was therefore changed to a palliative regimen with weekly docetaxel 35 mg:m2 . This chemotherapy was well tolerated, apart from PNP (peripheral