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Serum amyloid A is present in the capillaries and microinfarcts of hypertensive monkey brain: An immunohistochemical study

Details

Publisher
Informa UK Ltd
Copyright
© 2000 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
Subject
Original Article
ISSN
1350-6129
eISSN
1744-2818
D.O.I.
10.3109/13506120009146247
Publisher site
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Serum amyloid A is present in the capillaries and microinfarcts of hypertensive monkey brain: An immunohistochemical study

Abstract

Serum amyloid A (SAA) is a major inducible acute phase protein characterized as a transient injury specific constituent of high density lipoprotein. We investigated whether the acute phase SAA (A-apoSAA), as a marker of inflammation, is present in the brain of monkeys with surgically induced hypertension of 39 months duration. Sections from brains of normotensive monkeys (systolic blood pres-sure< 124 mmHg) and hypertensive monkeys (systolic blood pressure> 185 mmHg) were processed for immunohis-tochemistry with a rabbit polyclonal antiserum to human A-apoSAA. We found that A-apoSAA was present in hypertensive but not in normotensive brain sections. Staining was localized to capillary endothelial cells and occasionally to the entire vessel wall of the prefrontal cortex. Staining was also observed in the capillaries and in medium size vessels of the corona radiata, the head of the caudate and, to a smaller extent, in theputamen. Additionally, the A-apoSAA was present in cells forming a circular configuration within microinfarcts. These findings suggest that high blood pressure in the brain can result in either local production of A-apoSAA in the capillaries and within microinfarcts or uptake of A-apoSAA from the blood.
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