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selenoproteins in the cells , but thioredoxin reductase (TrxR) and glutathione peroxidase (GPx) are the most important selenoproteins in protecting cells from oxidative damage (Miller et al., 2002 ). TrxR ...
-like fold; protects neurons from oxidative stress Selenoprotein T (SelT) ER and Golgi Has Trx-like fold; redox regulation; plays a role in cell adhesion Selenoprotein S (SelS) ER membrane Upregulated ...
of GPX and protect the endothelial cell line Ea.hy926 cells from oxidative damage [29]. In our present study, we observed the expression of GPX1, GPX3 and GPX4 in HepG2 cells transfected with SEPP1 ...
), and glutathione reductase (GR). Glutathione peroxidase is a selenoenzyme with a selenocysteine in its catalytic center, and it protects the cells from oxidative damage . In particular, GPx protects hemoglobin from ...
, Involvement of selenoprotein P in protection of human astrocytes from oxidative damage , Free Radical Biol. Med. , 2006 , 40 , 1513 – 1523 . Google Scholar Crossref Search ADS WorldCat T. Lu , Y. Pan, S. Y. Kao ...
oxidative stress in bovine mammary epithelial cells (BMECs) by increasing antioxidant enzyme activities. However, the precise mechanism is unclear. The present study was conducted to examine the protective ...
, although important for protection during oxidative stress and found in many cells and tissues, may not be essential to the ability of a cell to survive oxidative damage . Selenoprotein W is highly expressed ...
high concentrations of superoxides are responsible for DNA damage ) protects cells from mitomycin C‐induced micronuclei formation [17, 18]. Cumulative damage contributes to aging processes of the organism ...
free radicals in the circulation for protecting vessels and endothelial cells .27 Moreover, high Cu concentrations are known for their bactericidal properties.31 In addition, CP is capable of oxidizing ...
activity has to be questioned. The ability of these compounds to oxidize the thiol groups of proteins (the thiol modifier effects of organoselenium compounds) and to spare selenoproteins from inactivation ...
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