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and the Emerging Role of Taxanes in Adjuvant Therapy LARRY NORTON Memorial Sloan-Kettering Cancer Center, New York, New York, USA Key Words. Adjuvant · Breast cancer · Gompertzian · Log kill · Paclitaxel · Docetaxel ...
(CMF). The benefits of adjuvant cytotoxic and endocrine treatments are additive. There is considerable debate as to the role of taxanes in adjuvant therapy . Improved outcome has been observed in one ...
the cardiotoxicity but with similar anticancer efficacy have called the role of anthracyclines into doubt. Taxane /trastuzumab-based chemotherapy without anthracyclines is now a widely accepted adjuvant regimen ...
,” and “chemotherapy,” for articles published between 1990 to 2015. In this review, we provide an overview of the evidence thus far supporting the use of taxanes in the concurrent, induction, and adjuvant settings ...
, the taxanes are now standard therapy in metastatic breast cancer. Their role as monochemotherapy or in combination with anthracyclines in advanced breast cancer has suggested their potential therapeutic impact ...
Abstract: The role of taxanes as adjuvant breast cancer therapy continues to evolve. In the first reported randomized trial (CALGB 9344) paclitaxel was evaluated in sequence to AC (doxorubicin ...
for the differences observed in these studies. The inclusion criteria for future clinical trials of adjuvant taxane therapy must be revised to account for the molecular heterogeneity of breast cancer. REv IEWS Taxanes ...
CMF. Regimens containing epirubicin are generally associated with prolongation in relapse-free and overall survival rates compared with standard therapies including CMF. Epirubicin- taxane combinations ...
Adjuvant treatment with anthracycline– taxane combination therapy in high-risk early-stage breast cancer has raised the important question of how to manage patients who relapse. In the metastatic ...
, adjuvant therapy improves survival outcomes the past two decades. Hormonal therapy and combination and cures a portion of the patients [1, 2]. chemotherapy based on anthracyclines and taxanes repre- In spite ...
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