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interlobar distribution of insoluble particles (U, PuO2) in the rat lung. Drew et al. (1987) found that the distribution of short and long glass fibers in rats exposed via intratracheal instillation ...
are restricted to the trachea , upper airways, and nasopharynx [4–7]. In general, transmission of influenza occurs through the generation of aerosol droplets in the nasopharynx followed by airborne transfer [8 ...
around CNT in rats after intratracheal administration of 1 or 5 mg/kg body weight (Warheit et al., 2004), although this study had some inconsistencies, such as the apparent lack of a persistent effect ...
1.5 feet above the neck) through the catheter into the lung for about 10 min. The trachea was then tied, and the isolated lung was placed in a glass vial containing about 10 ml of the same fixative (Lam ...
magnifications. Following dispersion into inhalation chambers, the airborne material was collected onto Nucleopore polycarbonate hydrophilic filters supported by a glass fiber filter. FIG. 1. View largeDownload ...
; Hardas et al., 2010; He et al., 2010; Hirst et al., 2009; Yokel et al., 2009, 2012). The distribution of nanocerium oxide in rats after a single intravenous administration has been demonstrated for tissues ...
of administration of each fluid. All fluids were filter-sterilized inside the BSC prior to use. Immediately following en bloc lung harvest, the airways of the tissue were inflated with PBS containing antibiotics (10 ...
), and effects of chronic exposure on lung retention of radiotracer particles (Finch et al., 1998) were reported previously. MATERIALS AND METHODS Animals and maintenance. Male and female CDF®(F344)/CrlBR rats ...
In animal experiments, retention half-times up to 240 days after long-term exposure under overload conditions were reported for rats .150 In addition to impaired clearance, secondary effects ...
through Whatman GF/C glass fiber filters and were washed with 10 mL of ice-cold incubation buffer. Radioactivity was quantified in a Packard Cobra γ-counter (Meriden, CT). Nonspecific binding was defined ...
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