Resistance to Prolonged Irradiation in Mice Influenced by Thyroid Hormones and Chemical Radiation Protectors
Abstract
Actri Radiologicri Otic~ology21 (1982) Fasc. 2 FROM THE INSTITUTE O F BIOPHYSICS. CZECHOSLOVAK ACADEMY OF SCIENCES, CS-61265 BKNO, CZECHOSLOVAKIA. RESISTANCE TO PROLONGED IRRADIATION IN MICE INFLUENCED BY THYROID HORMONES AND CHEMICAL RADIATION PROTECTORS B. HOSEK.J . MISUSTOVA, A. LOJEK J . K A U T S K A and The attainment of effective protection against prolonged whole-body irradiation meets with considerable difficulty, particularly in the case of lethal and supralethal doses. The known chemical radiation protectors with high DRF (dose reduction factor) values for acute irradiation decline heavily in effectiveness when irradiation is continued for several hours (BACQ 1965, VAN CANECHAM 1969, TIKHOMIROVA et coll. 1975). It was shown by POSPISIL et coll. (1975) that after feeding of mice for 21 days with a diet containing dried thyroid gland increased radiation resistance of animals occurs in the period during the fading away of the metabolic reaction. It was considered of interest to find out in what way the changes in radiation resistance of mice under the influence of thyroid hormones progress in the course of prolonged irradiation, and to try to increase the protective effect of chemical radiation protectors. The chemical protection used was a combination of propranolol,