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Abstract: Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily that regulates target gene transcription in a ligand‐dependent manner. Our earlier study indicated that reactive ...
Efavirenz (EFV), an antiretroviral that interacts clinically with co‐administered drugs via activation of the pregnane X receptor (PXR), is extensively metabolized by the cytochromes P450. We tested ...
anticoagulation potency than its optical congener. Recently, vitamin K2 function has been proposed via the pregnane X receptor (PXR) in osteocytes. PXR acts as a xenobiotic sensor that controls expression of many ...
pregnane X receptor and up- regulating DEC1 in human hepatoma HepG2 cells. 1. Introduction Cytochrome P450 3A4 (CYP3A4) is the most important human CYP450 enzyme because it contributes to the metabolism ...
products. Human pregnane X receptor (hPXR) is a ligand-activated transcription factor that regulates the expression of numerous hepatic drug-metabolizing enzymes, including several clinically important ...
Abstract Rifaximin, a nonsystemic antibiotic that exhibits low gastrointestinal absorption, is a potent agonist of human pregnane X receptor (PXR), which contributes to its therapeutic efficacy ...
determinants of bile formation and secretion. Nuclear receptors (NRs) are critically involved in the regulation of these hepatic transporters and are natural targets for therapy of cholestatic liver diseases ...
Abstract Mammalian liver contains a pregnane X receptor (PXR, NR1I2), which binds drugs and other xenobiotics, and stimulates (or suppresses) expression of numerous genes involved in the metabolic ...
for class II nuclear receptors , retinoid X receptor (RXR), which subsequently binds to the promoter or enhancer regions of PXR target genes (Guo et al., 2002; Kliewer, 2003; Kliewer et al., 1998; Lehmann et ...
and efflux . Nat Med 2001 ; 7 : 584 – 590 . Google Scholar Crossref Search ADS PubMed WorldCat 37 Goodwin B , Moore LB, Stoltz CM et al. Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor ...
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