Reactivity of a Free Radical Probe with Erythrocyte Membranes
AbstractINT . J . RAIIAT . BIOL ., 1975, VOL . 28, NO . 3, 267-272 CORRESPONDENCE Reactivity of a free radical probe with erythrocyte membranes ROGER H . BISBY and MICHAEL R . PRICE Cancer Research Campaign Laboratories, University Park, Nottingham NG7 2RD, England . ROBERT B . CUNDALL Chemistry Department, University Park, Nottingham NG7 2RD, England PETER WARDMAN Gray Laboratory of the Cancer Research Campaign, Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, England (Received 30 yune 1975 ; accepted 18 August 1975) 1. Introduction On structure of bio-membranes, there is a major controversy concerning the way in which protein molecules are disposed with respect to the lipid bilayer (Cook and Stoddart 1973, Hendler 1974) . The early Danielli-Davson model (Danielli and Davson 1934) showed the membrane protein associated with the polar head groups of the lipid and hence coating the lipid bilayer at the aqueous interfaces . More recently, much work, mainly with erythrocyte membranes, has indicated that protein is inserted into, or in some instances, spans the lipid bilayer (Steck, Fairbanks and Wallach 1971, Singer and Nicolson 1972, Marchesi, Tillack, Jackson, Segrest and Scott 1972, Juliano 1973, Steck 1974, Morris, Meuller and Huber 1974) .