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with thalidomide plus dexamethasone was significantly higher than with dexamethasone alone (n = 100; 63% versus 41%), with 4% versus 0% of patients achieving a CR [106]. The second, larger phase III trial , which ...
The FIRST (Frontline Investigation of Revlimid Plus Dexamethasone Versus Standard Thalidomide ) trial (MM-020/IFM07-01) is a randomized , international multicenter phase 3 trial (36–38). NDMM patients ...
. In addition, 21 phase I or II trials investigating single-agent temozolomide, temozolomide plus interferon-α, and temozolomide plus thalidomide were reviewed. A direct comparison of temozolomide and dacarbazine ...
, four‐drug combinations have been examined, for example, in a randomized phase II trial comparing bortezomib, thalidomide , dexamethasone, and cyclophosphamide with bortezomib, thalidomide ...
induction therapy with VCD plus high-dose therapy. The phase III GIMEMA trial also includes a consolidation randomization . Following induction treatment with VTD or TD and tandem transplantation, patients ...
known teratogenic effects of thalidomide , constipation, somnolence, and neuropathy were dose-limiting adverse effects in all clinical trials . In a Phase III trial of thalidomide plus dexamethasone versus ...
response (CR)/near CR and VGPR rates, the PFS interval was not significantly longer [22]. The combination of lenalidomide plus dexamethasone as induction has not been examined in a randomized phase III trial ...
WorldCat 29. Groves MD , Puduvalli VK , Chang SM , et al. A North American brain tumor consortium (NABTC 99-04) phase II trial of temozolomide plus thalidomide for recurrent glioblastoma multiforme . J ...
with bortezomib and dexamethasone alone is currently underway (OPTIMISMM trial ).22 In addition, a Phase I/ II trial evaluating the safety and efficacy of pomalidomide, liposomal doxorubicin, and dexamethasone ...
Placeholder Text WorldCat 63 Rajkumar SV , Blood E, Vesole D et al. Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: A clinical ...
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