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spontaneously in the brain as a result of normal physiological neuronal activity [50]. If not repaired , DNA SBs can block transcription, which is active at all cell cycle stages and particularly important ...
DNA repair status has required several assay procedures. We have developed a novel in vitro assay that allows quantitative measurement of alkylation repair via O6‐methylguanine DNA methyltransferase ...
) into neurons in culture for 48 h. DSB repair in neurons differentiated from NSPCs in culture was faster than that in mouse embryonic fibroblasts (MEFs), possibly due to the higher DNA -dependent protein kinase ...
reduced, even without a reduction in exogenous mutations. Here we present a review of quantitative data on the occurrence of endogenous DNA adducts in humans. Oxidative DNA damage In living cells ROS ...
), and deficiency of DNA -activated protein kinase-catalytic subunit ( DNA -PKcs), which impairs DSB repair . Consequently, DNA damage accumulates in patient cells , SMA mice neurons and patient spinal cord tissues ...
DNA repair capacity compared to treatment groups, which may reflect a culture medium with a nutrient-rich environment that is beneficial to cell metabolism (Paynter et al., 1999). DNA damage persisted ...
demonstrate that post radiotherapy temporal recruitment of NHEJ repair protein Ku80 via SETMAR mediated H3K36me2 is indispensable for DNA repair and survival of RR cells . Accordingly, conditional knockdown ...
showed different chromatin condensation, cell death, and DNA damage sensor activation. DNA damage accumulation and repair kinetics differed among human, mouse, and pig neurons. Promoter CpG island ...
-type and mutant mtDNA. We have demonstrated a method that can be used to quantitate cytoplasmic DNA synthesis rates in cultured cells . While this may be applicable to studies of viral replication ...
of cell division, the latter being modulated by cell -cycle delay at low-level DNA damage, and cell -cycle acceleration due to regenerative hyperplasia at cytotoxic dose levels. Quantitative analyses based ...
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