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of personalized medicine. Sarcoma, Hereditary , Cancer predisposition syndrome, Cancer genetics Implications for Practice: Sarcomas are uncommon malignancies that often occur sporadically but can also arise ...
Aims Breast cancer 1 (BRCA1) expression is down‐regulated in a significant proportion of non‐ hereditary breast cancers, in the absence of any mutation. This phenomenon is more pronounced in oestrogen ...
be associated with a poor outcome , is currently uncertain and has been the subject of much debate. Here, we outline some of the clinicopathological features of hereditary breast cancer, discuss the prognostic ...
of the most molecularly well-characterized tumors in humans. Molecular profiling of glioblastoma is increasingly available and had led to the identifications of multiple prognostic factors as well as potential ...
. Rezaeeyan H , Shahrabi S , McKee T , Saki N . The expression of CD markers in solid tumors: Significance in metastasis and prognostic value . Histol Histopathol. 2018 ; 33 ( 10 ): 1005 – 1012 . Google Scholar ...
], although TopBP1 has both prognostic and predictive significance , but not cancer predisposition . Karppinen et al. identified 19 TopBP1 germline variants in 125 families with breast or ovarian cancers [37 ...
-Lyonnet D, Longy M, Kerangueven F, Noguchi T, Bailly C et al. Germline mutation at BRCA1 affects the histo- prognostic grade in hereditary breast cancer . Cancer Res 1996 ; 56 : 471 – 4 . Google Scholar ...
Abstract Context Most hereditary ovarian cancers are associated with germline mutations in BRCA1 or BRCA2. Attempts to define the clinical significance of BRCA mutation status in ovarian cancer have ...
reduction or prevention in patients and their families. Characterizing hereditary genetic variation in high- and moderate-penetrance cancer predisposition genes may have implications for cascade carrier ...
of undetermined significance (VUS). To look for somatic alterations, a commercial test including sequencing of 168 genes was obtained, showing a p.E1559K mutation in exon 14 of BRCA1, classified as pathogenic ...
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