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ibuprofen . Preliminary results from this study suggested that the preparation of fast - dissolving ibuprofen SDs by low temperature melting method using PEG 6000 as a meltable hydrophilic polymer carrier could ...
solubilities, prepared by the solvent evaporation method. Solid dispersions of the three drugs in hydroxy-propylmethylcellulose (HPMC), with drug:polymer ratios of 1:4, were prepared and characterized ...
on the formulae. The DT limit of 30 s or less for orally disintegrating tablet described in Centre for Drug Evaluation and Research (CDER).[41] Guidance can be applied to fast dissolving oral strips; disintegration ...
on the in vivo behaviour of drug products is evaluated with in vitro techniques. This review focuses on the small and full scale in vitro methods to assess drug precipitation in the fasted small intestine. Key ...
)-2000] ammonium salt (PLGA-DSPE-PEG) with or without 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) hybrid nanoparticles has been prepared and evaluated for in-vitro characterization. Cytotoxicity ...
22 Cole ET et al. In vitro and in vivo pharmacoscintigraphic evaluation of ibuprofen hypromellose and gelatin capsules . Pharm Res 2004 ; 21 : 793 – 798 Google Scholar Crossref Search ADS PubMed ...
breakthrough in liposome research that the liposomes have the ability to localize in pathological sites spontaneously after intravenous (i.v.) administration by passive targeting. Thus, it was decided to prepare ...
dispersions were therefore prepared by first dissolving GF in the solvent, followed by PHPMA and finally PVP. Additionally, solid dispersions were prepared where PHPMA was added to the mixture either first ...
polyethylene glycol.[6] Among them, NMP is the most used because of its solvating ability and its low systemic toxicity when employed for the preparation of in-situ forming implants.[7] In a previous work[8] we ...
and to improve in-vivo absorption in the gastrointestinal (GI) tract, ITZ amorphous solid dispersions were prepared using the enteric polymer HPMCAS-LF which is very sensitive dissolved at pH 5.0~5.5 ...
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