Prenatal diagnosis of X-linked hydro-cephalus
Abstract
Journal of Obstetrics and Gynaecology (1994) 14, 162-165 Obstetric case reports Prenatal diagnosis cephalus of X-linked hydro- weeks because in this condition the ventriculomegaly may not become apparent before the end of the second trimester. E. OTENG-NTIM, M. MARTIN and K. H. NICOLAIDES Department of Obstetrics and Gynaecology, Basildon General Hospital, fssex, and Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London REFERENCES Halliday J., Chow C. W., Wallace D. and Danks D. M. ( 1986) X-linked hydrocephalus: a survey of a 20 year period in Victoria, Australia. Journal qf Medical Getietics 23, 23-3 I . Case report This was the second pregnancy of a 24 year old Caucasian woman. In her first pregnancy fetal hydrocephalus was diagnosed at 28 weeks and an abortion was performed; autopsy confirmed the hydrocephalus in an otherwise normal male fetus. The patient's mother and sister had both delivered stillborn hydrocephalic male babies. In this pregnancy. ultrasound scans at 10 and 20 weeks showed no fetal abnormality. A repeat scan at 25 weeks demonstrated a severe cerebral ventriculomepalv. The lateral ventricle to hemiwhere ratio was 0.6-(nknal mean for gestational age 0.35, 95th centile 0.3 1 ) and the third