“Woah! It's like Spotify but for academic articles.”

Instant Access to Thousands of Journals for just $40/month

Get 2 Weeks Free

Prednisone (M.S.D.) in the Treatment of Patients with Rheumatoid Arthritis Preliminary Report

Prednisone (M.S.D.) in the Treatment of Patients with Rheumatoid Arthritis Preliminary Report


I Grenblek, P : Acta Rheum. Scand., 2, 65-74, 1956. . I From The Physical Therapy Department Kommunehospitalet, Copenhagen, Denmark PREDNISONE (M.S.D.) IN T H E TREATMENT OF PATIENTS WITH RHEUMATOID ARTHRITIS Preliminary report BY P A L L E GRBNBAZK The intensive research during recent years to find new therapeutically useful adrenocortical steroids has given us several very active hormones. These new steroids include, La., two hormones with a predominant effect on the carbohydrate metabolism (Prednisone or Deltacortone and Prednisolone or Deltahydrocortone). The formula of this compound derived from cortisone (Prednisone) is shown below and is delta-1.4prednandiene-17 alpha, 21-diol-3.11.20-trione. P -0 H O PREDNISON These two new compounds have introduced a new era in the treatment of rheumatoid arthritis. In preliminary communications it has been reported that the antirheumatic potency of Prednisone is 3-5 times that 66 PALLE GRBNBAEK of cortisone, that the effect occurs rapidly and the toxicity is small. A t the same time it is found that in therapeutic doses Prednisone - unlike cortisone - does not cause retention of sodium and/or loss of potassium. A special diet and supplementation of potassium are not necessary. On the other hand, carbohydrate metabolism has changed; the
Loading next page...
Problems Reading this Article? Report Issue Here

You're reading a free preview. Subscribe to read the entire article.

And millions more from thousands of peer-reviewed journals, for only $40/month.

Get 2 Weeks Free

To be the best researcher, you need access to the best research

  • With DeepDyve, you can stop worrying about how much articles cost, or if it's too much hassle to order — it's all at your fingertips. Your research is important and deserves the top content.
  • Read from thousands of the leading scholarly journals from Springer, Elsevier, Nature, IEEE, Wiley-Blackwell and more.
  • All the latest content is available, no embargo periods.

Stop missing out on the latest updates in your field

  • We’ll send you automatic email updates on the keywords and journals you tell us are most important to you.
  • There is a lot of content out there, so we help you sift through it and stay organized.