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The relationship of plasma nortriptyline levels to the clinical response of 80 depressed patients was studied. Plasma nortriptyline levels were estimated 4 weeks after commencing treatment ...
Australian and New Zealand Journal of Psychiatry (1975) 9: 249 PLASMA NORTRIPTYLINE AND CLINICAL RESPONSE * by BRIAN DAVIES'F, GRAHAM BURROWS$ and BRUCE SCOGGINSI In the past few years measurement ...
and clinical response . Lancet 1:1297-1300, 1972.Crossref 24. Burrows G, Scroggins B, Turecek L, et al: Plasma nortriptyline and clinical response . Clin Pharmacol Ther 16:639-644, 1974. 25. Biggs J, Clayton P ...
nortriptyline and nortriptyline alone, and the clinical effect. The practical value of this type of investigation was demonstrated by showing that patients whose drug plasma level was not in the therapeutic range ...
78284 San Antonio TX USA Abstract The relationship between steady-state plasma concentration and clinical response was studied in 22 hospitalized unipolar depressed patients. In a double-blind format ...
to the tricyclic used for treatment, dosage, and plasma levels. Amitriptyline and its desmethyl metabolite, nortriptyline , were assayed twice weekly by gas chromatography‐mass fragmentography. For the 17 patients ...
variation in mean plasma nortriptyline levels, ranging from 120 µg/L to 681 µg/L. Patients with high plasma levels ( ...
, 1995 Keywords: Amitriptyline, nortriptyline , correlation, clinical response , patients SUMMARY Although many attempts have been made, to date no convincing evidence exists of a relationship between plasma ...
side effects. Clinical improvement appeared unrelated to whether plasma levels of nortriptyline were therapeutic. The implications of this regimen for accelerated antidepressant response as well ...
) and their clinical status was determined with the Hamilton Depression Rating Scale by raters blind to the drug type, its dosage and plasma levels. Amitriptyline (AT) and nortriptyline (NT) plasma levels were assayed ...
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