Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!
is a promising therapy in this setting. In a phase II trial investigating the safety and efficacy of capecitabine, 42 patients with advanced or metastatic pancreatic cancer received standard capecitabine ...
-synthelabo.us). Docetaxel and Paclitaxel Docetaxel and paclitaxel have demonstrated encouraging activity in the treatment of patients with advanced gastric cancer. Small phase II trials of single-agent paclitaxel ...
previous work showing that weekly gemcitabine could safely be combined with docetaxel and that four of the seven poor-risk patients treated had a response [29]. In the phase II trial , gemcitabine was given ...
and B12 supplementation [84]. Two phase II studies of single-agent pemetrexed in patients with locally advanced or metastatic colorectal cancer have been reported [79, 85]. Those trials resulted in response ...
( Taxotere ®; Sanofi-Aventis, Bridgewater, NJ) chemotherapy based on the data from two phase II trials [16–18]. Erlotinib was approved by the FDA in November 2004 for patients who had progressed after one ...
. Open in new tab Results of subsequent phase II trials showed lower and more variable response rates, ranging from 15% to 50% (Table 1), which may be due to differences in the dose and schedule ...
assessed in phase II trials . Results to date show promising activity and tolerability. Erlotinib, docetaxel , and pemetrexed are all approved for patients who progress following one prior regimen for advanced ...
be administered as normal. Phase II , Dose-Selection Study The three capecitabine regimens identified in phase I trials were evaluated further in a randomized, phase II trial in advanced colorectal patients ...
these three tumor types likely candidates for supplemental new drug applications. Clinical efficacy Colorectal cancer Bevacizumab has been studied in Phase II and III trials in over 1900 patients with meta ...
J Cancer 1998 ; 78 ( suppl 3 ): 21 – 25 . Google Scholar PubMed OpenURL Placeholder Text WorldCat 23 J Carmichael , K Possinger, P Phillip et al. Advanced breast cancer: a phase II trial ...
Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!