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and free prediction tools for the research community. We also discuss the challenges associated with the development of AI models for drug metabolism and excretion prediction and explore future perspectives ...
PROteolysis TArgeting Chimeras (PROTACs), as a recently identified technique in the field of new drug development, provide new concepts for disease treatment and are expected to revolutionize drug ...
. The identification of druggable target sites, promising hits, and high quality leads are crucial steps in the early stages of drug discovery projects. Pharmacokinetic (PK) and drug metabolism profiling to optimize ...
from lifestyle modification to drug treatment to surgery. Metabolic endoscopy (ME) might close the gap between invasive “ metabolic ” surgery and conservative, less effective treatment. In recent years ...
. In this review, we discuss the liver microphysiological platforms from the perspective of drug metabolism studies. We highlight the stand‐alone liver‐on‐a‐chip platforms and multi‐organ systems integrating liver ...
by either minimal benefits in the Coronary Drug Project or adverse noncardiovascular (non‐CV) effects in the World Health Organization Clofibrate Study. Fibrates returned for patients with low HDL‐C and low ...
and SLCO1B1) with Indian perspective . Review Article Indian J Med Res 139, January 2014, pp 27-65 Distribution of genetic polymorphisms of genes encoding drug metabolizing enzymes & drug transporters ...
AND PARENTERAL NUTRITION IN THE INTENSIVE CARE UNIT: A PHARMACEUTICAL AND METABOLIC PERSPECTIVE David F. Driscoll ABSTRACT: Since its inception, the field of parenteral nutrition has administration. As the field ...
discovery efforts. In this article, the covalent binding of drugs and other xenobiotics to proteins is reviewed from a historical perspective , and the evolution of the field is traced from an early dependence ...
Mammalian cytochrome P450 1A (CYP1A) are key phase I xenobiotic‐ metabolizing enzymes that play a distinctive role in metabolic activation or metabolic clearance of a variety of procarcinogens, drugs ...
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