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in patients with diabetes mellitus and with atherosclerotic cardiovascular disease . Approach and results: We assessed non ‑ invasive vascular function and mitochondrial DNA damage in 275 patients (age 57 ± 9 ...
-positive patients taking antiretroviral therapy. Awareness and knowledge of MS and DNA damage in HIV/AIDS patients may prove helpful to clinicians to manage non -AIDS diseases such as cardiovascular disease ...
in angiogenesis, oxidative stress and inflammation, thus fostering cardiovascular damage in patients with diabetes. Notably, adverse epigenetic signals acquired over the life course can be transmitted ...
that telomerase could prove to be a decelerator of atherosclerosis through its non -canonical pathway, antagonizing oxidative stress, DNA damage , and apoptosis, in addition to its effect on telomere length. Our ...
of this belief is that mitochondria are one of the major targets of environmental toxicants that can damage mitochondrial morphology, function and its DNA (manifested in non -communicable diseases ). In this article ...
of the levels of 8-OHdG is important as a biomarker of oxidative stress causing cellular DNA damage . Increased levels of 8-OHdG is associated with a lot of pathologic conditions like cancer, diabetes ...
of secondary reactive species, ultimately leading to cell death by necrosis or apoptosis. Oxidative damage of any of these biomolecules, if unchecked, can theoretically contribute to disease development. Indeed ...
instability and DNA damage response (DDR); the chronic inflammation associated with senescence causes cardiovascular damage . Therefore, vascular endothelial cell senescence is believed to induce ...
exposure to cardiovascular disease (CVD) risk factors such as environmental tobacco smoke (ETS) increased adult atherogenic susceptibility and mitochondrial damage ; however, the molecular effects of similar ...
DNA damage is a causative factor in ageing of the vasculature and other organs. One of the most important vascular ageing features is reduced nitric oxide (NO)soluble guanylate cyclase (sGC)—cyclic ...
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