Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!
(ceftazidime) and the carbapenems , imipenem and meropenem (Table 2). Comparing the resistance profiles of the variant enzymes in an identical genetic background allows assignment of any changes in resistance ...
as the principal mechanism of resistance against carbapenems (imipenem, meropenem ) [5], [6], [7]. MβLs degrade all classes of β-lactams except monobactams and, unlike most SβLs, these enzymes are not susceptible ...
The carbapenems are used as the last line of drugs for combating organisms such as Klebsiella pneumoniae, because of their stability against β-lactamases. However, with the increasing use of imipenem, resistance ...
, and the supernatant ( soluble protein fraction ) was used for protein purification. Recombinant protein was purified with the His-Bind protein purification kit (Novagen, Madison, WI, USA) according to the manufacturer's ...
), yet it provided little protection against carbapenems ( meropenem , imipenem, and doripenem). To dissect the genetic basis for the NAL-induced resistance to these β-lactams, we mutagenized Δbla cells ...
antibiotics, carbapenems . Based on the sequence, structure, and metal coordination number of MBLs, they are further divided into B1, B2, and B3 subclasses. Binuclear B1 and B3 MBLs are important drug targets ...
renal outcome. There was no difference in age (mean 65±2 vs. 68±4, p=1.00); hypertension (p=1.00); diabetes mellitus (p=0.61); peripheral vascular disease (p=0.33); systolic ejection fraction < 35% (p ...
higher amount of chitin and lower amount of glucan in the alkali-insoluble fraction compared to A. fumigatus conidial cell wall. Whereas, in the mycelial morphotype, the A. flavus cell wall showed ...
Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!