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Observations on Pain Perception and Hypertension in Spontaneously Hypertensive Rats

Details

Publisher
Informa UK Ltd
Copyright
© 1984 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
Subject
Original Article
ISSN
1064-1963
eISSN
1525-6006
D.O.I.
10.3109/10641968409039601
Publisher site
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Observations on Pain Perception and Hypertension in Spontaneously Hypertensive Rats

Abstract

Pain sensitivity in Spontaneously Hypertensive Rats (SHR) and normotensive Wistar-Kyoto controls (WKY) as well as in experimentally hypertensive Wistar rats has been studied. Results indicate a diminished responsiveness to noxious stimuli in SHR when compared with WKY. This hypoalgesia is altered neither by chronic treatment with the antihypertensive drugs hydralazine and captopril nor by the peripherally acting opiate antagonist N-methyl-naloxone. Induction of renal and DOCA-salt hypertension in Wistar rats and Wistar-Kyoto rats did not affect nociceptive responsiveness. It is concluded that opiate receptors within the central nervous system are involved in the hypoalgesia in SHR and that pain perception appears to be dissociated from blood pressure regulation in the rat strains used
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