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. Single nucleotide polymorphisms (SNPs) in the CD28 / CTLA4 / ICOS gene region were reported to be associated with several autoimmune diseases including, type-1 diabetes, SLE, autoimmune thyroid diseases ...
2003, Macmillan Publishers Ltd.) Fig. 4 Open in new tabDownload slide Association of SNPs within the CD28 - CTLA4 - ICOS gene region with GD. When association with GD was plotted for all the SNPs, a region ...
. The strong genetic associations between particular major histocompatibility antigens and susceptibility to autoimmune disease point to the importance of T cells in disease pathogenesis. T cell-directed ...
studies to estimate the impact of FAS, FASL, PTPN22, CTLA4 and IL2RA gene polymorphisms on AA susceptibility . Design A systematic literature search was conducted in the Medline, Web of Science, Scopus ...
autoimmunity with the heavy metals Hg, Ag and Au was assessed by studying strains with single- gene deletions on the metal- susceptible B10.S (H-2s) background. Previous studies on the effect of deleting IL-4 ...
counterpart of pTreg [6]. Epigenetic studies in tTregs and iTregs reveal that while there is full demethylation of the Treg specific demethylation region within Foxp3 gene in tTregs, which confers functional ...
), purified autoantibodies against CD28 were tested for their effects on CTLA-4-Ig-induced T cell anergy. In this study, for the first time, we describe the existence of autoantibodies against CD28 in humans ...
rarely proved successful as a primary approach to gene finding. GWAS offer major advantages both in power to detect variants with modest effects and in defining smaller genomic regions in which causal ...
. To assess these effects , we used a multicolor panel of antibodies to measure the level of expression of exhaustion ( CTLA4 , PD1, TIM3, and LAG3) and senescence (CD57 and KLRG1) markers on T cells from BC ...
of HTLV-1 infected cells. Analysis of the transcriptomes of 57 ATL cases using RNA-seq identified fusion gene products that contained five CD28 -related in-frame fusions ( CTLA4 - CD28 or ICOS - CD28 ) that likely ...
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