Metabolism and Pharmacokinetics of T-2 Toxin and Related Trichothecenes
Abstract
DRUG METABOLISM REVIEWS, 25(3), 281-323 (1993) METABOLISM AND PHARMACOKINETICS OF T-2 TOXIN AND RELATED TRICHOTH ECENES* BORIS YAGEN'.+ and MEIR BIALER2 'Department o Natural Products and 'Department of Pharmacy f School of Pharmacy, The Hebrew University Hadassah Medical Center PO Box 12065, Jerusalem 91120, Israel I. 11. INTRODUCTION.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . , , 282 CHEMICAL AND PHARMACOLOGICAL CHARACTERISTICS OF T-2 TOXIN. . . . . . . . . . . . . . . . . . A. Physical Properties . . . . . . . . . . . . . . . . . . . . . . . . . . . . B. Functional Groups in the T-Toxin Molecule Which Are Essential for Its Toxicity . . . . . . . . . . . . . . . . . . . . . . . . C. Mechanism of Action . . . . . . . . . . . . . . . . . . . . . . .