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To clarify the mechanism of action of Estracyt, we performed experiments using 3H_ estramustine of high specific activity. 3H‐Radioactivity accumulated selectively in the ventral prostate ...
Over two decades, experience with estramustine has provided limited data which support an estrogenic mechanism of action and no data which indicate the nitrogen mustard involvement in the cytotoxic ...
was assessed in vitro to evaluate possible mechanisms of action . In motility and cell cycle analysis assays, estramustine and colchicine inhibited cellular motility but not cell cycle transit. In vivo, these two ...
INFEZIONI DELLE BASSE VIE URINARIE and possible mechanism for its action in prostate cancer. N.Y. State ]. Med., 79; 1005 (1979). - Kadohama N., Kirdani R. Y.,"Murphy G. P., Sandberg A. A.: Estra ...
for the parenteral treatment of prostate carcinoma with estrogens, to study the mechanism of action of estramustine , and to identify markers useful as predictive tests for prostate carcinoma. CONCLUSIONS A model ...
These results are consistent with a MAP-microtubule mechanism of action for EM in ovarian carcinoma cells and provide reason to conduct further study of EM for potential use in the treatment of human epithelial ...
studied.CONCLUSIONS: These results are consistent with a MAP-microtubule mechanism of action for EM in ovarian carcinoma cells and provide reason to conduct further study of EM for potential use in the treatment ...
cancer and testicular cancer. The mechanism of action , based on the premature stabilization of the microtubule assembly with disruption of the cytoskeletal framework, is completely different from those ...
inhibitors and estramustine [46]. Table 7 Mechanism of action of microtubule inhibitors and of estramustine [46] • The anti-apoptotic protein, Bc1-2, is expressed in approximately 65% of androgen independent ...
observed in nonrandomized trials for patients with CRPC using ixabepilone in the first‐ and second‐line settings as a single agent and in combination with estramustine . Patupilone and sagopilone were also ...
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