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Integrated Pharmacokinetic-Dynamic Modeling of Drugs Acting on the CNS

Drug Metabolism Reviews , Volume 15 (1-2) – Jan 1, 1984

Details

Publisher
Informa UK Ltd
Copyright
© 1984 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
Subject
Research Article
ISSN
0360-2532
eISSN
1097-9883
D.O.I.
10.3109/03602538409015073
Publisher site
See Article on Publisher Site

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Integrated Pharmacokinetic-Dynamic Modeling of Drugs Acting on the CNS

Abstract

This paper has attempted to review some of the possibilities we have today to describe the relationships between the kinetics of a drug and the pharmacodynamic responses. In the future we should place a great deal of effort not only on a detailed evaluation of drug absorption and disposition in the body but also on a much more careful characterization of the dose (concentration)-effect relationships. This should be done in vivo, in order to be able to evaluate the complex character of an observed pharmacological effect, and in a dose range as wide as possible. Although not discussed in the present communication, the possibility of active metabolites must always be considered.
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